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. 2024 Sep 4;37:12827. doi: 10.3389/ti.2024.12827

TABLE 2.

Organ assessment with magnetic resonance imaging.

Publication details Study design Parameters measured for viability testing Imaging
Authors Animal Organ Hemodynamics Histology Blood parameters/gas contents Organ-specific Imaging method
Agius
2022 [19]
Pig Kidney - Cortical biopsies
Silver Jones and Periodic AcidSchiff staining
- Urine output T2-weighted imaging, dynamic contrast enhanced (DCE) MRI and 31P magnetic resonance spectroscopic imaging (pMRSI)
Liu
2007 [20]
Pig Liver - Hemotoxylineosin stained biopsies Aspartate
Aminotransferase (AST)
- Diffusion weighted MRI with contrast enhancement
Mariager 2020 [11] Pig Kidney Flow, pressure and temperature - Blood gas, metabolite and electrolyte values Urine production T1 and T2 imaging, hyperpolarized spectroscopy and/or spectral spatial imaging and dynamic contrast enhanced MRI
Mariager 2021 [21] Flow and pressure - Blood gas, metabolite and electrolyte values - CINE MR imaging, hyperpolarized spectroscopy and/or spectral spatial imaging and dynamic contrast enhanced MRI
Schutter 2021 [22] Pig and Human Kidney Flow and pressure Cortical punch biopsies Periodic acid– Schiff staining Arterial blood gas values Urine composition and production Arterial spin labelling (ASL)
Schutter 2023 [10] Pig and Human Kidney Flow, pressure and temperature - - Urine production T2- and T2*-weighted imaging, arterial spin labelling and hyperpolarized spectroscopy and/or spectral spatial imaging
Vaillant 2016 [23] Pig and
sheep
Heart Left ventricle pressure and flow - pH Heart rate and action potential Cine imaging, phase contrast for velocity-encoded cine flow imaging, T1 mapping with late gadolinium enhanced mapping and 31P MR spectroscopy.
Yang
2008 [24]
Pig Heart Pressure and resistance Heart slices analysed with near-infrared and various types of staining. Blood gas values Heart rate T1-weighted and contrast (Mn)enhanced MRI