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. 2024 Sep 17;2(1):33. doi: 10.1038/s44303-024-00037-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Experimental design. b Schematic of the infrarenal aorta undergoing surgery and magnetic resonance angiography (MRA) segment. c Both monomeric probes show enhancement up to 60 min post- injection. d [Gd-DOTAMA]₄-CBP1 and [Gd-DOTAMA]₄-CBP2 show stronger enhancement at 60 min compared with corresponding monomeric probes e The scrambled tetrameric Scc-CBP1 probe shows negligible enhancement but the Scc-CBP2 probe shows enhancement suggesting unspecific binding of the [Gd-DOTAMA]₄-CBP2 probe. f Signal enhancement observed by MRI co-localised with COL3 fibres (green) as seen by histology. L aortic lumen, HFD high-fat diet. Figure 4a and schematic in 4b were created with BioRender.com.