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. 2024 Sep 17;2(1):33. doi: 10.1038/s44303-024-00037-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Experimental design. b, c At day 10, enalapril-treated mice show similar MRI signal enhancement and T₁ relaxation times compared to untreated mice. At day 21, enalapril-treated mice show a significantly higher signal enhancement and reduced T₁ relaxation values (blue colour) compared with untreated. d, e Quantification of LGE volume shows significantly higher COL3 remodelling in enalapril-treated mice compared with untreated mice at day 21. Quantification of gadolinium uptake showed higher T₁ (lower gadolinium concentration) at day 21 compared with day 10 in untreated animals but similar values in enalapril-treated mice. f–i Cine MRI shows no significant changes in cardiac function between groups. LGE late gadolinium enhancement, and *P = 0.0233, **P = 0.0018, and ****P < 0.0001. RV right ventricle, LV left ventricle, PSR Picrosirius Red, BF bright field, PLM polarised light microscopy. Figure 6a was created with BioRender.com.