Table 3.
Linear models for associations of cognition with locus coeruleus tangle density and social activity.
| Model | β estimate (95% CI) | Test statistic | P-value |
|---|---|---|---|
| Model 4a | |||
| Age | −0.03 (−0.05 to −0.01) | −2.45 | 0.016 |
| Sex (reference: female) | −0.04 (−0.33–0.25) | −0.28 | 0.78 |
| Education | −0.03 (−0.08–0.03) | −1.00 | 0.319 |
| Depressive symptoms | −0.08 (−0.14 to −0.02) | −2.53 | 0.012 |
| LC Tangle Density | −0.13 (−0.18 to −0.07) | −4.63 | <0.001 |
| Model 4b | |||
| Age | −0.03 (−0.05 to −0.01) | −2.50 | 0.013 |
| Sex (reference: female) | −0.08 (−0.38–0.22) | −0.50 | 0.616 |
| Education | −0.04 (−0.09–0.01) | −1.55 | 0.124 |
| Depressive symptoms | −0.07 (−0.14 to −0.01) | −2.24 | 0.027 |
| Social activity | 0.35 (0.13–0.57) | 3.13 | 0.002 |
Bold values indicate statistical significance p < 0.05.
Social activity measurement was closest to the time of death.
Aβ Amyloid-beta, LC locus coeruleus.