Figure 2.

Effects of stereotaxic surgery on the circadian locomotor rhythm of 19–21-week-old mice. (A) Experimental timeline (grey: dark phase; white: light phase). (B) Activity of WT (left; n = 4) and TG (right; n = 5) mice during the light and dark phase of the day prior to surgery (pre-surgery), the day of surgery (day 0), and the days after surgery (days 1–11). p < 0.001 effect of surgery (mixed-effects analysis). # Light phase data for day 0 is not available as surgeries were conducted during this period. (C) Peak activity between 19 and 00 h. (D) Peak activity between 05 and 07 h. (E) Average activity during the dark phase (left y-axis) in comparison to body weight (right y-axis), both expressed as percentages of pre-surgery levels of WT and (F) TG mice. # Main effect of genotype; *p < 0.05.