TABLE 5.
TK mutations identified in PCV-selected HSV-1 SC16
| Clonal virus | Mutationa
|
Predicted length (aa)b | |
|---|---|---|---|
| Nucleotide | Amino acid | ||
| 1P1 | C424T; C860T | H142Y; T287M | 376 |
| 1P2 | T37C; ΔC553 | F13L; FS 185 | 346 |
| 1P3-A | G16T | G6C | 376 |
| 1P3-B | G559A; T614C | G200D; L205S | 376 |
| 1P4 | G16T | G6C | 376 |
| 1P5 | +C554 | FS 185 | 227 |
| 1P6 | C860T | T287M | 376 |
| 1P7 | +C700 | FS 234 | 375 |
| 1P8 | G559A; T800G | G200D; V267G | 376 |
| 1P9 | G559A | G200D | 376 |
| 1P10 | +T929 | FS 310 | 377 |
| 1P12 | +T364 | FS 122 | 227 |
a
The designation C424T represents a change from the wild-type nucleotide C to a T at base 424; the others follow this pattern. Δ, base deletion; +, base insertion; FS, frameshift in the coding sequence.
b
aa, amino acids.