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. 2024 Sep 18;15:8176. doi: 10.1038/s41467-024-52429-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic depiction of the CLA in primate (H. sapiens and C. jacchus) and rodent (R. norvegicus and M. musculus) brain and its location between the Insular cortex and Striatum. Yellow framed rectangles are centered on CLA and delineate the axis across the average OD traces were measured b Nurr1 mRNA is enriched in human (H. sapiens), marmoset (C. jacchus), rat (R. norvegicus) and murine (M. musculus) CLA. c Illustration of Nurr1+/− mouse line. d Left: ISH autoradiographs showing Nurr1 mRNA at CLA and SNc level. Right: Line-graphs (upper) and boxplots (lower) showing the Nurr1 mRNA OD quantification in CLA, L6b, SNc, CA1, and SUB of Nurr1+/+ and Nurr1+/− mice (Nurr1+/+: n = 7, Nurr1+/−: n = 8; CLA: *p < 0.0001, L6b: *p = 0.0067, SUB: *p = 0.0021, Two-sided Unpaired t-test). Data in line-graphs are expressed as mean ± SEM. Boxplots show all data points, the 25th and 75th percentile (box), the median (center), and the maxima (whiskers). OD: optic density, arb: arbitrary units, RIdg: rostral dysgranular insular cortex, Idg: insular dysgranular cortex, Cla: human claustrum/dorsal endopiriform cortex complex/dorsal endopiriform cortex complex, Pu: putamen, AI: agranular insula, CLA: rodent claustrum/dorsal endopiriform cortex complex/dorsal endopiriform cortex complex, CP: caudoputamen, AUC: area under the curve, FC: fold change, L6b: cortical layer 6b, SNr: substantia nigra reticular part, SNc: substantia nigra compact part, RN: reticular nucleus, TEa: temporal association areas, sr: stratum radiatum of CA1, mo: molecular layer of dentate gyrus, SUB: subiculum, fp: posterior forceps of corpus callosum. ISH: in situ hybridization. Source data are provided as a Source Data file.