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. 2024 Sep 17;15:8173. doi: 10.1038/s41467-024-52235-3

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 5 — A Overview of Depixus’ single-molecule MSF platform for exploring the interactions of bioactive small molecule ligands with their target RNA structures in real-time. B Unfolding force distributions of the Bsu PreQ₁ riboswitch aptamer in control, 4 and PreQ₁ ligand conditions. C Dose-response curve for the change in unfolding of the aptamer in the presence of 4 and PreQ₁. D Raw traces of the constant-force experiments for control, 4, and PreQ₁ of a single molecule with cumulative density histograms are shown to the right. E The aptamer unfolding rate as a function of the concentration of 4 in constant force experiments. F The impact of PreQ₁ ligand concentration on the occurrence probability of the stable folded state. n is the number of molecules analyzed, and the values represent mean ± standard deviation (SD).