Table 1.
Differentially methylated and expressed genes associated with ontogeny
| Symbol | RegionType | Gene | Correlation | P-Value | adjPValue |
|---|---|---|---|---|---|
| RHOH | promoters | ENSG00000168421 | − 0.76 | 2.31E-228 | 1.41E-226 |
| DENND2D | promoters | ENSG00000162777 | − 0.75 | 1.01E-221 | 2.05E-220 |
| ART4 | promoters | ENSG00000111339 | − 0.75 | 7.80E-217 | 1.19E-215 |
| CD3D | promoters | ENSG00000160654 | − 0.70 | 2.81E-176 | 2.14E-175 |
| LCK | promoters | ENSG00000182866 | − 0.69 | 1.17E-170 | 6.47E-170 |
| DGKA | promoters | ENSG00000065357 | − 0.68 | 9.51E-167 | 4.83E-166 |
| CHI3L2 | promoters | ENSG00000064886 | − 0.68 | 7.88E-164 | 3.43E-163 |
| CD28 | promoters | ENSG00000178562 | − 0.67 | 2.87E-161 | 1.10E-160 |
| PCED1B | promoters | ENSG00000179715 | − 0.67 | 1.22E-159 | 4.38E-159 |
| IL32 | promoters | ENSG00000008517 | − 0.65 | 3.37E-148 | 1.03E-147 |
| BACH2 | promoters | ENSG00000112182 | − 0.65 | 5.14E-148 | 1.49E-147 |
| TTC39C | promoters | ENSG00000168234 | − 0.64 | 7.26E-141 | 1.93E-140 |
| FYN | promoters | ENSG00000010810 | − 0.63 | 7.19E-135 | 1.76E-134 |
| CLEC2D | promoters | ENSG00000069493 | − 0.60 | 8.38E-121 | 1.83E-120 |
| S100A8 | promoters | ENSG00000143546 | − 0.60 | 4.02E-118 | 8.17E-118 |
| BASP1 | promoters | ENSG00000176788 | − 0.59 | 1.69E-116 | 3.22E-116 |
| RCAN3 | promoters | ENSG00000117602 | − 0.59 | 1.98E-115 | 3.67E-115 |
| HAL | promoters | ENSG00000084110 | − 0.59 | 1.49E-114 | 2.53E-114 |
| RUNX3 | promoters | ENSG00000020633 | − 0.58 | 1.06E-109 | 1.66E-109 |
| CDC25B | promoters | ENSG00000101224 | − 0.57 | 2.02E-104 | 2.93E-104 |
| NFE2 | promoters | ENSG00000123405 | − 0.55 | 6.87E-97 | 9.53E-97 |
| SCML4 | promoters | ENSG00000146285 | − 0.55 | 1.02E-96 | 1.39E-96 |
| FAM69A | promoters | ENSG00000154511 | − 0.55 | 2.92E-96 | 3.88E-96 |
| FAM134B | promoters | ENSG00000154153 | − 0.54 | 1.30E-91 | 1.58E-91 |
| TP53I11 | promoters | ENSG00000175274 | − 0.52 | 1.43E-85 | 1.61E-85 |
| FAR2 | promoters | ENSG00000064763 | − 0.52 | 1.59E-83 | 1.71E-83 |
| CD226 | promoters | ENSG00000150637 | − 0.51 | 2.77E-82 | 2.86E-82 |
| CD82 | promoters | ENSG00000085117 | − 0.51 | 7.45E-80 | 7.57E-80 |
Correlation: Pearson’s correlation coefficient between lead CpG in DMR (most significant) and transcript expression for genes within 1.5 kb from the DMR. P-values are shown from the Pearson’s coefficient test. P-values adjusted by False Discovery Rate.
An Abbreviated list of gene promoter associations is shown here, a complete set of regions in Supplementary Data 1.