Table 1.
Baseline characteristics of the NACC neuropathology database from participants with available neuropathology data.
| All (n = 6120) | Men (n = 3370) | Women (n = 2750) | |
|---|---|---|---|
| Mean age at death in years (range) | 80 (50-111) | 78 (50-110) | 81 (50-111) |
| Use of anticoagulants or antiplatelet therapy (%) a | 2347 (38) | 1399 (42) | 948 (35) |
| Mean interval between last UDS visit and death in months (range) | 20 (0-161) | 18 (0-152) | 22 (0-161) |
| APOE-ε4 b | |||
| One ε4 allele (n, %) | 2048 (34) | 1114 (33) | 934 (34) |
| Two ε4 alleles (n, %) | 504 (8) | 285 (9) | 219 (8) |
| Hypertension (n, %) c | 848 (14) | 459 (14) | 389 (14) |
| Hypercholesterolemia (n, %) d | 805 (13) | 469 (14) | 336 (12) |
| CAA pathology at autopsy e | |||
| None (n, %) | 2266 (37) | 1278 (38) | 988 (36) |
| Mild (n, %) | 1722 (28) | 926 (28) | 796 (29) |
| Moderate (n, %) | 1295 (21) | 697 (21) | 598 (22) |
| Severe (n, %) | 707 (12) | 402 (12) | 305 (11) |
| Thal phase at autopsy f | |||
| A0 (n, %) | 384 (6) | 245 (7) | 139 (5) |
| A1 (n, %) | 410 (7) | 237 (7) | 173 (6) |
| A2 (n, %) | 360 (6) | 188 (6) | 172 (6) |
| A3 (n, %) | 2125 (35) | 1104 (33) | 1021 (37) |
a
Missing/unknown n = 203.
b
Missing/unknown n = 737.
c
Missing/unknown n = 4385.
d
Missing/unknown n = 4414.
e
Missing/unknown n = 130.
f
Missing/unknown n = 2841.