Figure 1. Effect of maternal diabetes on placental miRNA profile and functional outcomes.

Pregnancies complicated by maternal diabetes are associated with a dysregulated placental miRNA and proteomic profile. As a result, studies have identified maternal diabetes leads to alterations in placental growth, insulin signalling and glucose uptake, epigenetic regulation, cell migration and invasion, vascular development, inflammation, autophagy and mitochondrial metabolism. Created using Biorender.com.