Figure 2.
Significant gene associations identified in exome-wide gene burden analysis across 12 traits and 12 diseases
The bars without outlines indicate the numbers of significant genes (p < 1.25 × 10−7) identified in each trait and disease by different masks. The bars with outlines indicate the number of significant genes that are also positive control genes for each trait and disease identified by different masks. The inset figure shows the total number of significant genes and positive controls identified by each mask across 21 tested traits and diseases that have at least one known positive control gene. eBMD, estimated bone mineral density; BMI, body mass index; WHR, waist-hip circumference ratio; LDL, serum low-density lipoproteins; T2D, type 2 diabetes.