FIGURE 1.

The role of neutrophil serine proteases (NSPs) in chronic inflammatory lung disease (cystic fibrosis (CF) lung disease and non-CF bronchiectasis). AAT: alpha-1 antitrypsin; CatG: cathepsin G; CFTR: CF transmembrane conductance regulator; Cl⁻: chloride; ECM: extracellular matrix; ENaC: epithelial sodium channel; Fab: antigen-binding fragment; Fc: crystallisable fragment; IgG: immunoglobulin G; IL: interleukin; MMP: matrix metalloproteinase; Na⁺: sodium; NE: neutrophil elastase; PR3: proteinase 3; SLPI: secretory leukocyte protease inhibitor; TNF: tumour necrosis factor.