Figure 1. 1a) Structure of RVM-6. 1b) RVM-6 improves synaptic viability in larvae exposed to oxidative stress.

a) Structure of RVM-6 prepared in the Lepore Laboratory. b) Average times to synaptic failure are shown for w ¹¹¹⁸ D. melanogaster 3 ^rd -instar larvae at different concentrations of Resveramorph 6 (RVM-6) in solution (total HL-3 n = 6; 2.25 mM H ₂ O ₂ n = 6; 0.1 nM RVM-6 + H ₂ O ₂ n = 2; 0.5 nM RVM-6 + H ₂ O ₂ n = 4; 1.0 nM RVM-6 + H ₂ O ₂ n = 6). HL-3 saline was a sham condition and positive control, and 2.25 mM H ₂ O ₂ was used as a negative control. Time to synaptic failure is the time in which it takes the excitatory junction potential to fall below a 1.00 mV threshold. Larvae exposed to the HL-3 sham condition averaged 199.2 minutes to reach synaptic failure. Animals exposed to 2.25 mM H ₂ O ₂ averaged 53.3 minutes to synaptic failure. Larvae exposed to 0.1 nM RVM-6 + H ₂ O ₂ averaged 75 minutes to reach synaptic failure. Larvae exposed to 0.5 nM RVM-6 + H ₂ O ₂ averaged 161.3 minutes to reach synaptic failure. Animals exposed to 1.0 nM RVM-6 + H ₂ O ₂ averaged 148.3 minutes to synaptic failure. Data are means ± the standard error of the mean (SEM). Statistical significance (p < 0.05) was designated utilizing letters where different letters indicate statistical differences, and the same letter indicates non-significance; one-way ANOVA and Holm-Sidak posthoc analysis.