No.	Recommendations/Statements	GoR	LoE	Sources
8.1	Adjuvant progestin therapy after surgery for endometrial cancer shall not be performed.	A	1	48
8.2	Patients with primary type I endometrial carcinoma stage pT1a/b G1 and G2 cN0/ pNsn0, p53-wt, shall not receive adjuvant chemotherapy.	EC
8.3	For patients with endometrioid or other type I endometrial carcinoma at stage pT1a G3 cN0 or pN0, p53-wt, there are insufficient data on the benefit of adjuvant chemotherapy.	ST	2	49
8.4	For patients with type I endometrial carcinoma G3 pT1b, without POLE mutation or stage pT2 (each pN0), adjuvant chemotherapy with 3 or 6 cycles (see Statement 8.13) may be considered as an adjunct to vaginal brachytherapy (see Radiation Therapy recommendation) or percutaneous radiotherapy alone without chemotherapy.	0	2	49 ,  50
8.5	Patients with type I endometrial carcinoma G3 pT1b or stage pT2 (both pN0) with POLE mutation should not receive adjuvant chemotherapy.	EC
8.6	Patients with serous endometrial carcinoma in FIGO stage I–III should receive adjuvant therapy according to the PORTEC-III regimen (= radiochemotherapy followed by chemotherapy). For stage III serous endometrial carcinoma, adjuvant chemotherapy alone can be given as an alternative (carboplatin AUC 6/paclitaxel 175 mg/m 2 ).	B	2	46 ,  51
8.7	Patients with type 1 endometrial carcinoma and abnormal p53 status on immunohistochemistry (type I endometrial carcinoma stage 1a or higher, with infiltration into the myometrium, or clear cell endometrial carcinoma) should be treated like patients with serous endometrial carcinoma.	EC
8.8	Patients with primary endometrial cancer stage pT3 and/or pN1 shall receive adjuvant chemotherapy or adjuvant therapy according to the PORTEC-3 regimen.	A	2	38 ,  39 ,  40 ,  46
8.9	Patients with stage pT4a or M1 endometrial cancer who have undergone macroscopic complete tumor resection or have a maximum postoperative residual tumor less than 2 cm should receive adjuvant chemotherapy, if applicable in combination with radiotherapy.	B	1	46 ,  49 ,  50
8.10	Adjuvant chemotherapy for endometrial cancer shall be given with carboplatin AUC 6 and paclitaxel 175 mg per square meter. After percutaneous radiotherapy, carboplatin AUC 5 should be dosed.	A	2	46 ,  52 ,  53
8.11	If chemotherapy alone is indicated and paclitaxel or carboplatin are contraindicated, adriamycin and cisplatin may also be used.	A	2	46 ,  52 ,  53
8.12	Patients with carcinosarcoma FIGO stage I or II may receive adjuvant chemotherapy with carboplatin/paclitaxel (at a dosage of paclitaxel 175 mg/m 2 day 1 carboplatin AUC 6 day 1) or cisplatin/ifosfamide (at a dosage of ifosfamide 1.6 g/m 2 day 1–4 and cisplatin 20 mg/m 2 day 1–4).	0	4	54
8.13	For patients with stage FIGO III or IV carcinosarcoma, adjuvant chemotherapy with ifosfamide/paclitaxel or ifosfamide/cisplatin was shown to have a significant survival benefit over monotherapy with ifosfamide.	ST	1	55 ,  56 ,  57
8.14	Given the high toxicity of ifosfamide-containing combinations, the combination of carboplatin and paclitaxel can also be used as adjuvant chemotherapy in patients with stage FIGO III or IV carcinosarcoma at a dosage of paclitaxel 175 mg/m 2 day 1 and carboplatin AUC 6 or cisplatin/ifosfamide at a dosage of ifosfamide 1.6 g/m 2 i.v. day 1–4 and cisplatin 20 mg/m 2 i.v. day 1–4.	EC