No.	Recommendations/Statements	GoR	LoE	Sources
6.2	In patients with endometrial carcinoma (all stages and histologies), the lymph nodes that appear enlarged on laparoscopic or open inspection of the abdominal cavity and/or are susspicuous on palpation (“bulky nodes”) shall be removed.	EC
6.3	Lymph node sampling of inconspicuous lymph nodes shall not be performed.	EC
6.4	When surgical lymph node staging is performed in patients with endometrial cancer, it shall be performed as a systematic LNE or sentinel node biopsy rather than sampling.	EC
6.5	In low-risk type I endometrial carcinoma pT1a, G1/2, no bulky nodes, systematic lymphadenectomy shall not be performed.	A	1	11
6.6	If pT1a (without myometrial infiltration), G1/G2, a p53 mutation (intermediate risk), or L1CAM overexpression (high-intermediate risk) is present in a type I endometrial carcinoma, a sentinel node biopsy can be performed, followed by systematic LNE if necessary.	EC
6.7	If a type I endometrial carcinoma cT1a, G3, or cT1b, G1/2 and no p53 mutation (i.e., at least an intermediate risk endometrial carcinoma) is present preoperatively, sentinel node biopsy can be performed, followed by systematic LNE if necessary. Primary systematic LNE should be omitted.	EC
6.8	In endometrial cancer type I, cT1b, G3 (high-intermediate risk group), surgical lymph node staging – sentinel LNE or (sentinel-assisted) systematic LNE – should be performed.	EC
6.9	If type I endometrial carcinoma cT1a, G3, or cT1b, G1/2 and a p53 mutation (high risk) are present preoperatively, surgical lymph node staging – sentinel LNE and/or (sentinel-assisted) systematic LNE – should be performed.	EC
6.10	If extensive lymphatic vessel invasion (at least high-intermediate risk group) is present in endometrial carcinoma type I stage I, pT1a G1-G3, pT1b G1/G2, a systematic LNE should be performed, even if no other risk factors are present. If a negative sentinel is present, LNE can be omitted.	EC
6.11	In endometrial carcinoma type I, pT2 to pT4, M0, G1-3, (sentinel-assisted) systematic lymphadenectomy should be performed if macroscopic tumor resection can be achieved.	EC
6.12	If bulky nodes are present in patients with endometrial cancer (all stages, all histologies), sentinel node biopsy is no longer informative.	ST	4	12
6.13	In endometrial carcinoma type II, (sentinel-assisted) systematic lymphadenectomy should be performed if complete tumor resection can be achieved macroscopically.	EC
6.14	If systematic LNE is indicated, it should be performed pelvic and infrarenal-para-aortic.	B	3	13 ,  14 ,  15 ,  16 ,  17 ,  18
6.15	For carcinosarcomas of the uterus, (sentinel-assisted) systematic LNE should be performed.	EC
6.16	The combination of systematic LNE and sentinel biopsy (that is, sentinel-assisted LNE) may improve the detection of positive lymph nodes.	EC
6.17	If sentinel node biopsy is performed, it should be done according to the following algorithm: Laparoscopy and visualization of the situs (adhesiolysis if necessary) Intracervical injection of ICG A re-injection of ICG, if necessary If only unilateral visualization of a sentinel is possible despite re-injection of ICG, a systematic pelvic LNE should be performed on the ICG-negative side (except in pT1a/G1-2) Work-up of the sentinel lymph node by ultrastaging (details see background text)	EC