Table 4. Univariate analysis of factors associated with NEC occurrence.
| Variables | NEC group(n=23) | No NEC group(n=23) | P value |
| Prostaglandin (days), median (IQR) | 6.8 (3.83–11.00) | 6.21 (4.00–8.00) | 0.39 |
| Maximal dose of prostaglandin (µg/kg/min), median (IQR) | 0.05 (0.038–0.05) | 0.047 (0.029–0.06) | 0.08 |
| Minimal dose of prostaglandin (µg/kg/min), median (IQR) | 0.025 (0.013–0.042) | 0.016 (0.006–0.034) | 0.36 |
| Epinephrine, n (%) | 11 (47.8) | 19 (82.6) | 0.017 |
| Maximal dose of epinephrine (µg/kg/min), median (IQR) | 0 (0–0.06) | 0.04 (0.02–0.14) | 0.057 |
| Norepinephrine, n (%) | 9 (39.1) | 11 (47.8) | 0.55 |
| Maximal dose of norepinephrine (µg/kg/min), median (IQR) | 0 (0–0.09) | 0 (0–0.07) | 0.32 |
| ECMO, n (%) | 3 (13.0) | 4 (17.4) | 0.5 |
| Antibiotics, n (%) | 15 (65.2) | 18 (78.3) | 0.326 |
| Antifungal, n (%) | 3 (13.0) | 2 (8.1) | 0.636 |
| Transfusion, n (%) | 17 (73.9) | 14 (60.9) | 0.345 |
| Peritoneal dialysis, n (%) | 4 (17.4) | 13 (56.5) | 0.007 |
| Breastfeeding, n (%) | 15 (68.2) | 10 (43.5) | 0.095 |
| Feeding volume (mL/kg/day), mean (SD) | 47.6 (±39.3) | 61.2 (±24.6) | 0.368 |
| Fasting (days), median (IQR) | 3 (0–6) | 2 (1–4) | 0.31 |
| Clinical data | |||
| Minimal DBP, (mm Hg), mean (SD) | 26.1 (±3.9) | 30.3 (±5.8) | 0.008 |
| Minimal NIRSv, (%), median (IQR) | 37.9 (25.8–44.5) | 44.6 (33.6–53.9) | 0.083 |
| Input–output fluid balance (mL/kg/day), median (IQR) | −19.6 (−31.9–−2.18) | −49.4 (−60.2–−29.38) | 0.002 |
| Biological data | |||
| Acute renal failure | 16 (69.5) | 15 (65.2) | 0.518 |
| Lactates (mmol/L), median (IQR) | 5.5 (4–10.7) | 5.6 (4.3–10.8) | 0.771 |
| Haematocrit (%), mean (SD) | 33.3±7.3 | 30.2±5.6 | 0.531 |
| pH min, mean (SD) | 7.14±0.14 | 7.2±0.14 | 0.098 |
| pH max, mean (SD) | 7.52±0.09 | 7.59±0.08 | 0.083 |
| Peroperative data | |||
| Age at surgery, (days), median (IQR) | 16.5 (7–26.5) | 7.5 (6.75–13.25) | 0.018 |
| Length of CPB (min), median (IQR) | 144.5 (0–206.25) | 79 (0–166.25) | 0.2 |
| Length of clamping (min), median (IQR) | 50 (0–109.25) | 28 (6–95) | 0.39 |
| Temperature min (°C), mean (SD) | 28.8 (±7.4) | 31.2 (±5.3) | 0.25 |
| Length of stay | |||
| ICU (days), median (IQR) | 28 (14–42) | 9 (6–18) | 0.0001 |
| Hospital (days), median (IQR) | 59 (39–103) | 23 (20–45) | 0.001 |
| Death, n (%) | 8 (34.8) | 2 (8.7) | 0.035 |
CPB, cardiopulmonary bypass; DBP, diastolic blood pressure; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unitMax, maximal; Min, minimal; NECnecrotising enterocolitisNIRSv, visceral near infrared spectroscopy