Table 2.

BMI, cause of admission, vitamin C level, comorbidities, treatment, and outcome of patients with scurvy and anorexia nervosa.

Author	Weight, Height, BMI	Cause of Admission	Vitamin C Serum (RV: 0.4–2.0 mg/dL)	Comorbidities	Treatment	Outcome
da Silva et al. (18)	27.7 kg, 138 cm, 14.57 kg/m2	Pain and purpuric lesions on lower limbs, gingival edema	Ascorbic acid was not measured	Healthy, no comorbidities	100 mg of oral vitamin C thrice daily for 1 week, followed by 100 mg of oral vitamin C once daily	7 days after treatment start, substantial recovery with improved diet, mood, and lower limb pain.
Du & Kulkarni (19)	N/A	Progressive and spreading rash on lower limbs, gingival edema, menorrhagia	<0.09 mg/dL (measured 4 days after discharge)	Not reported	Oral vitamin C supplements, dosage not specified	N/A
Gisondi & Bellinato (16)	N/A	N/A	<0.1 mg/dL	Not Reported	Not Reported	N/A
Levavasseur et al. (33)	N/A	Purpura and spontaneous hematomas on lower limbs	Ascorbic acid was not measured	Chronic Hepatitis C, Iron Deficiency, history of drug addiction	1 g of oral vitamin C daily for 1 month	1 month after treatment start for complete recovery.
Martin-Benllock et al. (20)	42.5 kg, 167 cm,15.24 kg/m2	Cachexia, severe malnutrition	0.06 mg/dL	Anxiety, no DSM diagnosis	1 g of oral vitamin C daily for 1 month. 100 mg of oral iron daily and 5 mg of folate daily.	4 days after treatment start, substantial improvement of joints, skin, and gait.
Peixoto et al. (17)	N/A, N/A, 11.4 kg/m2	Failure to respond to outpatient treatment	Ascorbic acid was not measured	Not reported	300 mg of oral vitamin C daily for 6 weeks	14 days after treatment start, improved cutaneous signs
Roy-Lavalee et al. (21)	33.1 kg, 170.2 cm, 11.43 kg/m2	Cachexia, low weight and cardiovascular support for bradycardia, poor peripheral perfusion, hypotension, dehydration	0.23 mg/ dl	Healthy, no comorbidities	250 mg of oral vitamin C daily. Paediatric multivitamin that included 50 mg of sodium ascorbate daily.	4 weeks after treatment start, improved cutaneous signs
Christopher et al. (22)	38.6 kg, 165 cm, 14.18 kg/m2	Cachexia	Ascorbic acid was not measured	Nephrolithiasis, malnutrition, and normocytic anemia. Surgical history included hysterectonomy, bilateral salpingo-oophorectomy,	Treated with ascorbic therapy via vitamin supplements and enteral supplements. Did not specify duration.	7 days after treatment start, complete recovery.
Mehta et al. (23)	44 kg, 157.5 cm, 17.74 kg/m2	Cachexia (myalgia, weakness, fatigue) and purpura in lower limbs	0.2 mg/dL	Amenorrheic since birth	supplemental vitamin C and other supportive therapies. Did not specify duration.	12 days after treatment start, substantial recovery.