Table 2.
ORs and HRs with 95% CIs for the association between base excess and ICU/hospital/28-day/1-year mortality
| Regression models | Base excess (mmol/L) | ||||
|---|---|---|---|---|---|
| -3–3 | < -3 | > 3 | |||
| ICU mortality | OR (95%CI) | P- value | OR (95%CI) | P- value | |
| Event, n (%) | 139 (12.90) | 77 (24.40) | 26 (14.90) | ||
| Univariable model | 1 (ref) | 2.183 (1.597–2.984) | < 0.001 | 1.183 (0.752–1.860) | 0.468 |
| Multivariable Model 1 | 1 (ref) | 1.768 (1.263–2.475) | 0.001 | 1.193 (0.757–1.880) | 0.447 |
| Multivariable Model 2 | 1 (ref) | 1.780 (1.264–2.507) | 0.001 | 1.229 (0.775–1.949) | 0.381 |
| Multivariable Model 3 | 1 (ref) | 1.795 (1.266–2.546) | 0.001 | 1.293 (0.809–2.066) | 0.283 |
| Multivariable Model 4 | 1 (ref) | 1.829 (1.281–2.612) | 0.001 | 1.190 (0.737–1.921) | 0.477 |
| Hospital mortality | OR (95%CI) | P- value | OR (95%CI) | P- value | |
| Event, n (%) | 124 (20.70) | 97 (30.70) | 34 (19.40) | ||
| Univariable model | 1 (ref) | 1.695 (1.280–2.244) | < 0.001 | 0.923 (0.617–1.379) | 0.695 |
| Multivariable Model 1 | 1 (ref) | 1.448 (1.072–1.957) | 0.016 | 0.928 (0.620–1.388) | 0.715 |
| Multivariable Model 2 | 1 (ref) | 1.454 (1.069–1.978) | 0.017 | 0.938 (0.622–1.415) | 0.760 |
| Multivariable Model 3 | 1 (ref) | 1.460 (1.066–2.001) | 0.019 | 0.955 (0.628–1.452) | 0.829 |
| Multivariable Model 4 | 1 (ref) | 1.484 (1.077–2.045) | 0.016 | 0.877 (0.572–1.344) | 0.547 |
| 28-day mortality | HR (95%CI) | P- value | HR (95%CI) | P- value | |
| Event, n (%) | 264 (24.40) | 117 (37.00) | 39 (22.30) | ||
| Univariable model | 1 (ref) | 1.664 (1.339–2.069) | < 0.001 | 0.901 (0.644–1.261) | 0.543 |
| Multivariable Model 1 | 1 (ref) | 1.499 (1.187–1.893) | 0.001 | 0.908 (0.649–1.271) | 0.573 |
| Multivariable Model 2 | 1 (ref) | 1.489 (1.180–1.879) | 0.001 | 0.895 (0.639–1.253) | 0.517 |
| Multivariable Model 3 | 1 (ref) | 1.482 (1.173–1.873) | 0.001 | 0.928 (0.660–1.304) | 0.668 |
| Multivariable Model 4 | 1 (ref) | 1.522 (1.200-1.929) | 0.001 | 0.884 (0.628–1.244) | 0.480 |
| 1-year mortality | HR (95%CI) | P- value | HR (95%CI) | P- value | |
| Event, n (%) | 389 (36.00) | 165 (52.20) | 70 (40.00) | ||
| Univariable model | 1 (ref) | 1.678 (1.399–2.014) | < 0.001 | 1.104 (0.856–1.424) | 0.446 |
| Multivariable Model 1 | 1 (ref) | 1.468 (1.207–1.785) | < 0.001 | 1.119 (0.867–1.443) | 0.387 |
| Multivariable Model 2 | 1 (ref) | 1.483 (1.221–1.802) | < 0.001 | 1.079 (0.836–1.392) | 0.559 |
| Multivariable Model 3 | 1 (ref) | 1.405 (1.153–1.711) | 0.001 | 1.052 (0.812–1.363) | 0.701 |
| Multivariable Model 4 | 1 (ref) | 1.399 (1.148–1.705) | 0.001 | 1.051 (0.811–1.361) | 0.707 |
Multivariable Model 1 was adjusted for the SOFA score
Multivariable Model 2 was adjusted for model 1 plus age, sex, and ethnicity
Multivariable Model 3 was adjusted for model 2 plus admission diagnoses including diabetes, hypertension, hyperlipemia, malignant neoplasm, chronic kidney disease, heart failure, chronic hepatic failure, chronic respiratory failure, sepsis, disseminated intravascular coagulation, pneumonia and diarrhea
Multivariable Model 4 was adjusted for model 3 plus treatment measures, including vasoactive drugs, sedatives, anticoagulants, mannitol, mechanical ventilation
ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment; OR, odds ratio; HR, hazard ratio; CI, confidence interval