Table 5.
Overview of ventilation defects (VD) distribution for different quadrants, methods, and registration algorithms.
| ANTs | |||||||
|---|---|---|---|---|---|---|---|
| CT | JVent | RVent* | Omnibus ANTS | CT vs. JVent | CT vs. RVent* | JVent vs. RVent* | |
| UR | 0.23 (0.02–0.50) | 0.54 (0.23–0.89) | 0.14 (0.01–0.41) | 4.47e−27 (****) | 1.87e−12 (****) | 9.53e−05 (****) | 2.98e−22 (****) |
| UL | 0.14 (0.02–0.44) | 0.60 (0.20–0.96) | 0.13 (0.01–0.35) | 5.44e−28 (****) | 3.36e−16 (****) | 1.28e−02 (*) | 1.72e−23 (****) |
| LR | 0.42 (0.11–0.65) | 0.16 (0.04–0.36) | 0.38 (0.12–0.60) | 9.86e−13 (****) | 6.50e−12 (****) | 2.85e−01 (n.s.) | 1.52e−15 (****) |
| LL | 0.37 (0.08–0.56) | 0.10 (0.02–0.32) | 0.42 (0.12–0.60) | 1.15e−15 (****) | 1.45e−11 (****) | 2.58e−01 (n.s.) | 2.37e−17 (****) |
| Omnibus quadrants | 3.28e−13 (****) | 3.86e−45 (****) | 7.27e−22 (****) | ||||
| UR vs. LR | 1.51e−05 (****) | 6.92e−22 (****) | 3.12e−11 (****) | ||||
| UL vs. LL | 6.77e−08 (****) | 1.98e−23 (****) | 6.87e−14 (****) | ||||
| F-REG | |||||||
|---|---|---|---|---|---|---|---|
| CT | JVent | RVent* | Omnibus F-REG | CT vs. JVent | CT vs. RVent* | JVent vs. RVent* | |
| UR | 0.23 (0.02–0.50) | 0.47 (0.30–0.81) | 0.20 (0.08–0.43) | 1.04e−23 (****) | 4.13e−14 (****) | 5.88e−02 (n.s.) | 1.66e−23 (****) |
| UL | 0.14 (0.02–0.44) | 0.58 (0.37–0.79) | 0.20 (0.07–0.35) | 6.99e−33 (****) | 7.15e−18 (****) | 6.89e−01 (n.s.) | 2.65e−25 (****) |
| LR | 0.42 (0.11–0.65) | 0.27 (0.17–0.39) | 0.44 (0.19–0.66) | 5.66e−06 (****) | 5.87e−05 (****) | 2.64e−01 (n.s.) | 1.14e−09 (****) |
| LL | 0.37 (0.08–0.56) | 0.25 (0.15–0.39) | 0.46 (0.21–0.66) | 2.23e−07 (****) | 8.82e−03 (**) | 3.78e−04 (***) | 3.09e−12 (****) |
| Omnibus quadrants | 3.28e−13 (****) | 6.39e−29 (****) | 2.49e−17 (****) | ||||
| UR vs. LR | 1.51e−05 (****) | 3.61e−17 (****) | 1.22e−10 (****) | ||||
| UL vs. LL | 6.77e−08 (****) | 1.42e−19 (****) | 3.30e−14 (****) | ||||
| M-REG | |||||||
|---|---|---|---|---|---|---|---|
| CT | JVent | RVent* | Omnibus M-REG | CT vs. JVent | CT vs. RVent* | JVent vs. RVent* | |
| UR | 0.23 (0.02–0.50) | 0.75 (0.70–0.77) | 0.65 (0.59–0.74) | 1.16e−35 (****) | 4.91e−24 (****) | 6.57e−22 (****) | 2.65e−19 (****) |
| UL | 0.14 (0.02–0.44) | 0.77 (0.72–0.80) | 0.68 (0.60–0.75) | 3.71e−38 (****) | 1.01e−24 (****) | 2.84e−23 (****) | 6.14e−17 (****) |
| LR | 0.42 (0.11–0.65) | 0.70 (0.66–0.75) | 0.71 (0.63–0.78) | 2.50e−21 (****) | 3.78e−19 (****) | 5.68e−20 (****) | 3.60e−01 (n.s.) |
| LL | 0.37 (0.08–0.56) | 0.73 (0.68–0.78) | 0.73 (0.64–0.81) | 6.11e−27 (****) | 7.76e−21 (****) | 1.04e−22 (****) | 9.17e−01 (n.s.) |
| Omnibus quadrants | 3.28e−13 (****) | 2.99e−10 (****) | 7.98e−03 (**) | ||||
| UR vs. LR | 1.51e−05 (****) | 6.40e−06 (****) | 1.91e−02 (*) | ||||
| UL vs. LL | 6.77e−08 (****) | 5.66e−05 (****) | 1.76e−03 (**) | ||||
Significantly higher VDJVent were present in the upper lung regions in comparison to the lower regions for ANTs and for F-REG. RVent showed a reversed relationship for ANTs and F-REG similar to CT. Respective omnibus and post-hoc test results for differences regarding quadrants (omnibus quadrants) and parameters (omnibus registration abbreviation) are included as well. p ≤ 0.05 (*), p ≤ 0.01 (**), p ≤ 0.001 (***), p ≤ 0.0001 (****). Please note that the numbers displayed in this table are rounded to two decimal places. As a result, different values may appear identical despite minor differences in their actual values. ANTs: advanced normalization tools, F-Reg: Forsberg registration, M-Reg: Matlab registration, RVent*: filtered regional ventilation, JVent: Jacobian determinant ventilation, UR: upper right, UL: upper left, LR: lower right, LL: lower left, VD: ventilation defect.