Table 6.

Two-class overlap coefficient of ventilation defect (VD) and ventilated volume (VV) of RVent and JVent with CT as gold standard for different quadrants and registration algorithms.

	ANTs			F-REG			M-REG
Description	RVent*	JVent	RVent* vs. JVent	RVent*	JVent	RVent* vs. JVent	RVent*	JVent	RVent* vs. JVent
UR	0.72 (0.59–0.89)	0.62 (0.44–0.77)	4.54e−07 (****)	0.68 (0.54–0.86)	0.57 (0.44–0.71)	3.21e−08 (****)	0.46 (0.39–0.54)	0.37 (0.29–0.53)	2.81e−10 (****)
UL	0.73 (0.54–0.90)	0.53 (0.34–0.77)	2.49e−10 (****)	0.70 (0.52–0.87)	0.51 (0.37–0.64)	3.36e−12 (****)	0.43 (0.32–0.53)	0.32 (0.23–0.47)	2.14e−12 (****)
LR	0.60 (0.52–0.76)	0.56 (0.42–0.76)	5.72e−04 (***)	0.59 (0.51–0.71)	0.53 (0.42–0.70)	6.04e−06 (****)	0.49 (0.41–0.60)	0.44 (0.35–0.55)	8.39e−09 (****)
LL	0.58 (0.48–0.74)	0.53 (0.41–0.83)	6.97e−02 (n.s.)	0.55 (0.46–0.68)	0.50 (0.41–0.76)	3.69e−03 (**)	0.47 (0.36–0.56)	0.42 (0.30–0.53)	4.15e−06 (****)
Omnibus quadrants	1.19e−11 (****)	1.23e−01 (n.s.)	—	1.77e−07 (****)	2.74e−02 (*)	—	4.22e−07 (****)	1.10e−16 (****)	—
UR vs. LR	9.43e−09 (****)	− (−)	—	2.26e−06 (****)	3.04e−01 (n.s.)	—	2.75e−02 (*)	4.93e−05 (****)	—
UL vs. LL	2.49e−06 (****)	− (−)	—	5.74e−06 (****)	3.44e−02 (*)	—	8.11e−03 (**)	4.75e−07 (****)	—

Especially for UR and UL, RVent showed significantly higher overlaps. p ≤ 0.05 (*), p ≤ 0.01 (**), p ≤ 0.001 (***), p ≤ 0.0001 (****). Please note that the numbers displayed in this table are rounded to two decimal places. As a result, different values may appear identical despite minor differences in their actual values. ANTs: advanced normalization tools, F-Reg: Forsberg registration, M-Reg: Matlab registration, RVent*: filtered regional ventilation, JVent: Jacobian determinant ventilation, UR: upper right, UL: upper left, LR: lower right, LL: lower left, VD: ventilation defect.