FIG. 4.

Influence of viral titer and route of infection on development of a TH1 or TH2 response. C3H mice were infected i.c. with 10⁴ PFU of MV (strain CAM/RBH), and the MV-specific TH response of surviving animals was tested (a). Other animals were infected i.p. (b) or i.c. (c) with 10⁴ PFU of MV (strain Edmonston [ED]). i.c. infected animals did not display clinical signs. Supernatants from MV-specific CD4⁺ T cells (derived from spleen cells) were assayed 48 to 72 h after stimulation for the presence of IFN-γ, IL-4, IL-5, and IL-10 by ELISA (error bars indicate standard deviations).