TABLE 1.

Proliferation and cytokine production of MV-specific CD4⁺ T cells^a

CD4+ T-cell type	MV-specific T-cell proliferation (SI ± SD)	Amt of cytokine produced (± SD)
		IFN-γ (ng/ml)	IL-4 (ng/ml)	IL-5 (pg/ml)
IFN-γ−/−	8.6 ± 1.5	ND	ND	ND
IFN-γ+/+	7.8 ± 1.2	18 ± 4.36	ND	ND

^aProliferation and cytokine production of MV-specific CD4⁺ T cells are identical. C57BL/6 mice (IFN-γ^+/+ and IFN-γ^−/−) were immunized with 3 × 10⁶ PFU of MV (Edmonston strain). One week later, the generation of MV-specific CD4⁺ T cells was measured in a proliferation assay. To determine the cytokine profile of MV-specific CD4⁺ T cells, spleen cells were stimulated with UV-inactivated MV. After 72 h, the amounts of cytokines in the supernatant (IFN-γ, IL-4, and IL-5) were measured. SI, stimulation index; ND, not detected.