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. 2024 Sep 4;17:1431549. doi: 10.3389/fnmol.2024.1431549

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Copyright © 2024 Sade, Fischel, Barak-Broner, Halevi, Gottfried, Bar-On, Sachs, Mirelman, Thaler, Gour, Kestenbaum, Gana Weisz, Anis, Soto, Roitman, Shahar, Doppler, Sauer, Giladi, Lev, Alcalay, Hassin-Baer, and Ashery.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Steps and methodology of skin biopsy processing for dSTORM. (A) Skin biopsy taken from the upper back (C7). (B) The skin contains various innervated structures, such as erector pili muscles, sweat glands, autonomic nerves, and cutaneous nerves. (C,D) Confocal image of a sweat gland from PD patient: p-aSyn (red), neuronal marker PGP9.5 (green) and areas of co-localization (yellow). (E) dSTORM reconstructed image of part of the sweat gland innervation (insert in D) shows p-aSyn (red) and PGP9.5 (green) and their co-localization (yellow). Insert-a close-up view showing single-molecule distribution of both p-aSyn (red) and PGP9.5 (green).