Fig 7. Change in Standard PRS disease effect size with age.

Difference in PRS effect size (log hazard ratio per SD of PRS, based on incident events over the next 10 years) between younger (40–49) and older (60–69) age-at-first-assessment groups. Standard PRSs are presented and evaluated in all UKB individuals with European ancestries, to maximise case numbers. Alzheimer’s disease, asthma, psoriasis, schizophrenia and type 1 diabetes are omitted, because they are primarily diagnosed outside the UKB age range. Bars indicate 95% CI. Refer to Fig 1 legend for disease abbreviations.