Table I.
Signaling network during Agrin-induced regeneration.
| Author(s), year | Cell type | Function | Targets | Mechanism | (Refs.) |
|---|---|---|---|---|---|
| Bassat et al, 2017 | Cardiomyocyte | Promotes division | DGC/YAP | Disassembly of the DGC, and Yap- and ERK-mediated signalling | (9) |
| Zhang et al, 2019 | NSPCs | Neurogenesis | LRP4/Ror2 | Promotes adult neurogenesis through proliferation and maturation of NSPCs | (22) |
| Jing et al, 2021 | Epicardial Cells | Promotes proliferation | YAP | Increases the expression of Ki67, pH3 and Aurora B through YAP | (74) |
| Hou et al, 2020 | Limbal stem cells | Promotes proliferation | YAP/Cyclin D1 | Facilitates the dephosphorylation of Yap1 and activates transcription of Cyclin D1 | (76) |
| Eldridge et al, 2016 | Chondrocyte | Differentiation | LRP4/DAG/DKK1 | Inhibition of WNT pathway and promotion of SOX9 expression | (86) |
| Eldridge et al, 2020 | Chondrocyte | Differentiation | LRP4/DAG/CaMKII | Inhibition of WNT signaling in a CREB-dependent manner | (87) |
| Chakraborty et al, 2021 | Keratinocytes | Enhances mechanically competent | MMP-12 | Overhauls cytoskeletal architecture via enhancing actomyosin cables | (122) |
| Chakraborty et al, 2018; Calvo et al, 2013 | Cancer cell | Carcinogenesis | MuSK | Inhibition of the Hippo pathway by promoting the FAK-ILK-PAK1 axis | (3,124) |
| Sun et al, 2021 | Epicardial cells | Regulator of EMT | β-catenin/pFAK | Enhances EMT by decreasing β-catenin and promoting pFAK localization and the aggregation of dystroglycan | (125) |
LRP4, low-density lipoprotein receptor-related protein 4, DKK1, dickkopf WNT signaling pathway inhibitor 1; DAG, dystroglycan; FAK-ILKPAK1, focal adhesion kinase-integrin linked kinase-p21 activated kinase; CaMKII, calcium/calmodulin-dependent protein kinase II; DGC, dystrophin-glycoprotein complex; Musk, muscle-associated receptor tyrosine kinase; NSPCs, neural stem/progenitor cells; YAP, yes-associated protein; EMT, epithelial-mesenchymal transition.