. Author manuscript; available in PMC: 2024 Oct 1.

Published in final edited form as: Biochem Pharmacol. 2024 Apr 5;228:116191. doi: 10.1016/j.bcp.2024.116191

Table 2.

Stepwise linear regression analysis of cytochrome P450 (CYP) activities as measured by specific metabolite formation from probe substrates and THC metabolite formation. Y ~ X indicates the linear regression with Y as a response variable and X as the predictor. Added predictor as indicated was included to the linear regression one at a time to determine whether it improves the goodness of fit. The absolute p-value from the analysis of variance (ANOVA) test is shown.

Linear Regression	Added Predictor	P-value
11-OH-THC ~ CYP2C9	CYP3A	0.949
	CYP2C19	0.122
M2 ~ CYP3A	CYP2C9	0.369
	CYP2C19	0.728
M3 ~ CYP3A	CYP2C9	0.0721
	CYP2C19	0.00000000000880
M3 ~ CYP3A + CYP2C19	CYP2C9	0.344
M4 ~ CYP3A	CYP2C9	0.594
	CYP2C19	0.844