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Kinetic parameter estimates of THC metabolite formation in pooled human liver microsomes. The data are reported as means ± standard deviation from experiments done on 3 separate days. N.D. Not determined due to lack of saturation of the metabolite formation.
| 11-OH-THC | M2 | M3 | M4 | |
|---|---|---|---|---|
| Km,unbound (nM) | 1.4 ± 0.2 | > 45 | > 45 | > 45 |
| Vmax (pmol/min/mg HLM) | 521 ± 53 | N.D. | N.D. | N.D. |
