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Expression of ER‐stress mRNA suggests dysregulation of the UPR in the skeletal and heart muscles of Yoshida AH‐130 rats. A: expression of ATF4, B) GADD34, and C) spliced XBP‐1 normalized to total XBP‐1 mRNA in skeletal muscle and heart. Data are presented as mean fold‐change from controls ± SEM. Statistical significance was determined by a two‐tailed unpaired t‐test, P = significant differences from control.
