Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Aug 26;633(8030):710–717. doi: 10.1038/s41586-024-07809-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 3 — A. Many protein clusters contain a mix of annotated and unannotated sequence clusters. Each “wheel” of nodes indicates a protein cluster, with individual nodes representing individual sequence clusters. Each sequence cluster node is colored based on if it is annotated (gray) or unannotated (red). All protein clusters with at least one annotated and one unannotated protein cluster are shown. Numbers below each wheel indicate the cluster ID. B-G. (Left) A network of sequence clusters that belong to each protein cluster, where nodes that are red are unannotated and those that are gray are annotated. The centroid is the protein cluster representative. (Right) Members of annotated and unannotated sequence clusters are highlighted, where the structure of an annotated protein (left) is compared to the structure of an unannotated protein (right). Proteins are colored based on pLDDT, with red indicating higher pLDDT and blue indicating lower pLDDT. The RMSD between the two structures is indicated.