Table 1.
One DEP in each group was enriched in pathways associated with pulmonary fibrosis.
| Signaling Pathway | Symbol | Log2FC (COVID19/Control) | Qvalue (COVID19/Control) | Log2FC (PQ/Control) | Qvalue (PQ/Control) |
|---|---|---|---|---|---|
| Wnt | TLE3 | 2.334363041 | 0.001068722 | ||
| PPP3CA | 0.773500039 | 0.003699282 | 0.6622182 | 0.01814957 | |
| RAC1 | 1.342190105 | 0.0129168 | |||
| CAMK2G | 1.152841075 | 0.01739589 | |||
| DAAM1 | -2.255988917 | 0.03492649 | |||
| PLCB4 | -0.970277022 | 0.03501096 | |||
| RAC2 | 1.71137878 | 0.03606512 | |||
| CACYBP | 1.028170908 | 0.03758443 | |||
| CTBP1 | 0.674958809 | 0.04614673 | |||
| NFATC2 | 0.510556441 | 0.1327327 | 1.582644 | 0.0143101 | |
| SERPINF1 | 0.817230288 | 0.05481924 | 1.052233 | 0.03618222 | |
| PLCB1 | -1.20737 | 0.03868567 | |||
| SMAD4 | -1.040178 | 0.04678961 | |||
| TGF-β | FMOD | 1.525054828 | 0.01041436 | 2.231091 | 0.002736285 |
| MAPK1 | 0.570629695 | 0.0190492 | |||
| SMAD4 | 0.07558513 | 0.8568159 | -1.040178 | 0.04678961 | |
| PI3K-Akt | TNC | 3.598133523 | 0.00000236 | 4.72209 | 0.000000801 |
| FN1 | 2.289614174 | 0.00005523 | 3.027061 | 0.00001898 | |
| ITGA2B | -1.628314963 | 0.000300505 | -1.235885 | 0.004655138 | |
| PPP2R5E | 2.469928867 | 0.000501024 | |||
| BAD | 2.710905434 | 0.000802183 | |||
| SGK3 | 1.803091666 | 0.000895442 | |||
| CDC37 | 1.323246163 | 0.001123117 | |||
| TSC2 | 1.541233867 | 0.001862487 | |||
| MAP2K2 | 3.062623437 | 0.00289972 | 2.921303 | 0.01187354 | |
| HSP90AB1 | 1.791747126 | 0.00385903 | |||
| GRB2 | 1.304040067 | 0.007280749 | |||
| YWHAH | 0.887984554 | 0.007413334 | |||
| RAC1 | 1.342190105 | 0.0129168 | |||
| GNB2 | 0.709724132 | 0.01713441 | |||
| PKN2 | -1.821455022 | 0.0187558 | |||
| MAPK1 | 0.570629695 | 0.0190492 | |||
| YWHAB | 0.777029311 | 0.01932895 | |||
| SYK | -0.913971923 | 0.02196084 | |||
| EPHA2 | 1.352442423 | 0.02538842 | 1.211464 | 0.04666163 | |
| CHUK | -1.789637666 | 0.02650397 | |||
| NFKB1 | 1.140610106 | 0.02687618 | |||
| MAP2K1 | 1.355991046 | 0.03054679 | |||
| YWHAZ | 0.606165866 | 0.03620794 | |||
| ITGB3 | -1.680240038 | 0.04077571 | |||
| RELA | 1.559710702 | 0.0416755 | 1.836263 | 0.03861816 | |
| EIF4B | 1.79392172 | 0.04528951 | |||
| AKT1 | 1.113971 | 0.02168375 | |||
| ITGA5 | 1.510934 | 0.01126765 | |||
| IKBKB | 2.243506 | 0.007500147 | |||
| ITGA4 | 1.839896 | 0.04634894 | |||
| COL6A3 | 1.932291 | 0.02196405 | |||
| Hedgehog | ARRB1 | 1.090237398 | 0.04105257 | 1.295323 | 0.03666427 |
| Notch1 | TLE3 | 2.334363041 | 0.001068722 | ||
| NCSTN | 1.696530228 | 0.001345855 | 1.036378 | 0.03873798 | |
| CTBP1 | 0.674958809 | 0.04614673 | |||
| DTX3L | -1.377831 | 0.04540409 | |||
| Hippo | PPP1CA | 0.86048615 | 0.00279096 | ||
| YWHAH | 0.887984554 | 0.007413334 | |||
| YWHAB | 0.777029311 | 0.01932895 | |||
| TP53BP2 | -1.486384353 | 0.02616206 | |||
| YWHAZ | 0.606165866 | 0.03620794 | |||
| SMAD4 | -1.040178 | 0.04678961 |
A blank box illustrates undetected proteins that showed no statistically significant difference.