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. 2024 Aug 31;33(4):165–179. doi: 10.5607/en24014

Fig. 1.

Fig. 1

Effects of different intensity (15 or 30 RPM) of exercise on the reserpine (RSP, 1 mg/kg)-induced pain and body weight variation in mice. (A, B) Physical exercise performed using a rota-rod tester at an intensity of 15 or 30 RPM inhibited the RSP-induced reduction of the paw withdrawal threshold (A). Area under curve was analyzed in control, RSP-treated, and RSP-treated exercised (15 or 30 RPM) groups (B). (C, D) The RSP-treated exercised (30 RPM) group of mice display lower body weight variation (%) relative to control mice (C). Area under the curve was analyzed and shown in D. (E) The number of falls in rota-rod tester during exercise was increased in the exercised group at an intensity of 30 RPM. n=5~7 mice/group. *p<0.05, **p<0.01, ***p<0.001 vs Control; #p<0.05, ##p<0.01, ###p<0.001 vs RSP; ††p<0.01 vs RSP+EXR15.