Fig. 2.

Effects of different intensity (15 or 30 RPM) of exercise on the reserpine (RSP, 1 mg/kg)-induced depression-like behaviors in mice. (A) Physical exercise performed using a rota-rod tester at an intensity of 15 or 30 RPM inhibited the RSP-induced increased immobility time (sec) during the forced swimming test. (B~D) Representative images for visualization of the path of movement during the open field test (B). The RSP-treated exercised (15 RPM) group of mice showed a significant increase in the total moved distance (C) and the number of crossings in the box during the open field test (D). n=5~7 mice/group. *p<0.05, **p<0.01, ***p<0.001 vs Control; ^#p<0.05, ^##p<0.01 vs RSP; ^†p<0.05, ^††p<0.01 vs RSP+EXR30.