Fig. 4.

Effects of physical exercise (15 RPM), gabapentin (GBP, 50 mg/kg), and fluoxetine (FLU, 10 mg/kg) on the reserpine (RSP, 1 mg/kg)-induced pain and body weight variation in mice. (A, B) Not only physical exercise at an intensity of 15 RPM but also GBP or FLU administration inhibited the RSP-induced reduction of the paw withdrawal threshold, but FLU was less effective than physical exercise and GBP administration (A). Area under curve was analyzed in control, RSP-treated, RSP-treated exercised (15 RPM), RSP and GBP-treated, RSP and FLU-treated groups (B). (C, D) There was no difference in body weight variation (%) between control and experimental groups (C). Area under the curve was analyzed and shown in D. n=10~14 mice/group. ^###p<0.001 vs RSP; ^‡‡‡p<0.001 vs RSP+FLU.