Fig. 5.

Effects of physical exercise (15 RPM), gabapentin (GBP, 50 mg/kg), and fluoxetine (FLU, 10 mg/kg) on the reserpine (RSP, 1 mg/kg)-induced depression-like behaviors in mice. (A) Administration of GBP or FLU inhibited the RSP-induced increased immobility time (sec) during the forced swimming test, but less effectively than physical exercise. (B~D) Representative images for visualization of the path of movement during the open field test (B). Administration of GBP or FLU restored the RSP-induced decrease in the total moved distance (C) and the number of crossings in the box during the open field test, but less effectively than physical exercise (D). n=10~14 mice/group. ^##p<0.01, ^###p<0.001 vs RSP; ^†p<0.05, ^††p<0.01, ^†††p<0.001 vs RSP+GBP; ^‡p<0.05, ^‡‡p<0.01 vs RSP+FLU.