Table 3. Two-Sample Mendelian Randomization (MR) Examining for Risk-Increasing MR Associations Between Cardiovascular Traits and Common Immune-Mediated Diseases.
| Outcome (immune-mediated disease) | Coronary artery disease (exposure) [234 variants] | Stroke (exposure) [47 variants] | ||
|---|---|---|---|---|
| OR (95%CI) | One-tailed P value | OR (95% CI) | One-tailed P value | |
| Atopic dermatitis | 1.03 (0.96-1.10) | .18 | 0.91 (0.77-1.08) | .86 |
| Acne | 0.96 (0.91-1.00) | .97 | 0.92 (0.77-1.09) | .85 |
| Asthma | 0.97 (0.94-1.01) | .92 | 0.87 (0.80-0.94) | >.99 |
| Multiple sclerosis | 1.06 (0.94-1.19) | .17 | 0.83 (0.66-1.04) | .95 |
| Celiac disease | 1.00 (0.99-1.01) | .36 | 0.99 (0.98-1.02) | .60 |
| Rheumatoid arthritis | 0.92 (0.84-1.01) | .95 | 1.00 (0.81-1.23) | .48 |
| Inflammatory bowel disease | 0.97 (0.91-1.04) | .80 | 0.95 (0.81-1.13) | .71 |
| Crohn disease | 0.95 (0.88-1.04) | .87 | 1.00 (0.81-1.24) | .49 |
| Ulcerative colitis | 0.99 (0.93-1.06) | .58 | 0.92 (0.79-1.09) | .83 |
Abbreviation: OR, odds ratio.