Percentage of growth inhibition by the compounds 4a–4v measured via MTT assaya.
| Entry | Compound | MDA-MB-231 | MCF-7 | ZR-75-1 |
|---|---|---|---|---|
| 1 | 4a | 00 | 0.85325 | 00 |
| 2 | 4b | 00 | 9.20334 | 00 |
| 3 | 4c | 16.79 | 17.62 | — |
| 4 | 4d | 15.81 | 21.27 | — |
| 5 | 4e | 12.78 | 18.35 | — |
| 6 | 4f | 7.98 | 16.10 | — |
| 7 | 4g | 17.09 | 8.99 | — |
| 8 | 4h | 15.27 | 5.714 | — |
| 9 | 4i | 23.06 | 20.18 | — |
| 10 | 4j | 10.4327 | 32.79543 | 8.544045 |
| 11 | 4k | 22.74293 | 57.59924 | 12.09783 |
| 12 | 4l | 16.41 | 16.41 | — |
| 13 | 4m | 5.766997 | 48.63073 | 2.392276 |
| 14 | 4n | 22.62 | 13.37 | — |
| 15 | 4o | 23.50 | 28.87 | — |
| 16 | 4p | 23.35 | 23.34 | — |
| 17 | 4q | 32.11751 | 51.2877 | 6.413226 |
| 18 | 4r | 17.43 | 00 | — |
| 19 | 4s | 5.251687 | 35.85265 | 4.94602 |
| 20 | 4t | 31.61213 | 58.51736 | 21.21026 |
| 21 | 4u | 22.62 | 13.37 | — |
| 22 | 4v | 17.92 | 21.21 | — |
| 23 | Positive controlb | 37.90 | 45.47 | 45.49 |
a
The experiment was performed with a 10 μM concentration of each compound for 48 h.
b
Doxorubicin (1 μM) was used as a positive control.