Table 2.
Top 25 downregulated genes in the Y-33075-treated group versus the control solvent group
| Gene ID | Gene name | log2 Fold Change | padj |
|---|---|---|---|
| Ccl2 | C–C motif chemokine ligand | − 4.767 | 4.64E-19 |
| Qpct | Glutaminyl-peptide cyclotransferase | − 4.774 | 2.20E-299 |
| Fam135b | Family with sequence similarity 135, member B | − 4.811 | 6.41E-303 |
| Stab1 | Stabilin 1 | − 4.916 | 6.31E-62 |
| Slc24a4 | Solute carrier family 24 member 4 | − 4.994 | 0.00E + 00 |
| Gpr179 | G protein-coupled receptor 179 | − 5.01 | 1.15E-204 |
| Lyz2 | Lysozyme 2 | − 5.135 | 2.76E-54 |
| Sebox | SEBOX homeobox | − 5.306 | 1.39E-238 |
| Gabrr1 | Gamma-aminobutyric acid type A receptor subunit rho 1 | − 5.339 | 0.00E + 00 |
| Cfh | Complement factor H | − 5.384 | 3.97E-64 |
| C1qa | Complement C1q A chain | − 5.399 | 1.25E-29 |
| Grm6 | Glutamate metabotropic receptor 6 | − 5.54 | 0.00E + 00 |
| C1qc | Complement C1q C chain | − 5.657 | 7.41E-46 |
| Gsg1 | Germ cell associated 1 | − 5.751 | 7.46E-112 |
| Cx3cr1 | C-X3-C motif chemokine receptor 1 | − 5.772 | 1.55E-46 |
| Lrit2 | Leucine-rich repeat, Ig-like and transmembrane domains 2 | − 5.932 | 8.24E-68 |
| Tafa3 | TAFA chemokine like family member 3 | − 5.963 | 1.40E-234 |
| C1qb | Complement C1q B chain | − 5.967 | 1.89E-25 |
| Csf1r | Colony stimulating factor 1 receptor | − 6.232 | 6.17E-90 |
| Lactbl1 | Lactamase beta like 1 | − 6.266 | 5.21E-170 |
| Ncf1 | Neutrophil cytosolic factor 1 | − 6.329 | 6.25E-76 |
| Ptgds | Prostaglandin D2 synthase | − 6.378 | 3.55E-250 |
| Adgre1 | Adhesion G protein-coupled receptor E1 | − 6.841 | 1.44E-54 |
| Pcp2 | Purkinje cell protein 2 | − 7.392 | 4.28E-229 |
| Lrit1 | Leucine-rich repeat, Ig-like and transmembrane domains 1 | − 7.804 | 0 |