Table 5.
Major secondary metabolites identified by antismash on Dolichospermum lemmermannii FEM_B0920.
| BGC type | Region length (bp) | Most similar known cluster | Similarity | Property |
|---|---|---|---|---|
| NRPS | 8935 | anabaenopeptin/nostamide—NRP | 44% | Phosphatases and proteases inhibition/antimicrobial, cytotoxic |
| NRPS | 4026 | anabaenopeptin—NRP | 42% | Phosphatases and proteases inhibition |
| NRPS | 13 791 | scytocyclamides—NRP+Polyketide | 38% | Antifungal activity, cytotoxicity |
| NRPS | 37 118 | varlaxin—NRP | 9% | Aeruginosin-type inhibitors of human trypsins |
| Cyanobactin | 12 623 | anacyclamide—RiPP:Cyanobactin | 35% | Antibacterial |
| Cyanobactin | 4478 | anacyclamide—RiPP:Cyanobactin | 28% | Antibacterial |
| hglE-KS, T1PKS | 32 443 | heterocyst glycolypids | 85% | Involved in heterocyte glycolipids biosynthesis |
| hglE-KS | 37 883 | heterocyst glycolypids | 57% | Involved in heterocyte glycolipids biosynthesis |
| Terpene | 22 274 | geosmin—Terpene | 100% | Impart earthy/musty taste and odor |
| Mycosporine-like | 16 006 | hexose-palythine-serine/hexose-shinorine—NRP | 28% | MAAs protection against UV damage |
BGC, biosynthetic gene cluster; NRPS, non-ribosomal peptide synthase; PKS, polyketide synthase; hglE-KS, heterocyst glycolipid synthase-like PKS; RiPP, ribosomally synthesized and post-translationally modified peptide product. Only secondary metabolite regions showing similarity to a known biosynthetic cluster are shown. Similarity indicates the percentage of genes within the closest known compound that has a significant BLAST hit to genes within the current region (Blin et al. 2023).