Table 3.
Jadomycin B biosynthetic genes and proposed functions
| Gene | Proposed Function | Gene | Proposed Function |
|---|---|---|---|
|
| |||
| jadW1 | Regulator | jadK | Hydrolase |
| jadW2 | Regulator | jadL | Efflux pump |
| jadW3 | Regulator | jadM | Phosphopantetheinyl transferase |
| jadR2 | Transcriptional regulator | jadN | Malonyl-coenzyme A decarboxylase |
| jadR1 | Transcriptional regulator | jadX | Unknown |
| jadJ | Acetyl-coenzyme A carboxylase | jadO | NDP-hexose-2,3-dehydratase |
| jadI | Cyclase | jadP | NDP-hexose-3-ketoreductase |
| jadA | Ketoacyl synthase | jadQ | NDP-glucose synthase |
| jadB | Chain length factor | jadS | Glycosyltransferase |
| jadC | Acyl carrier protein | jadT | NDP-hexose-4,6-dehydratase |
| jadE | Ketoreductase | jadU | NDP-hexose-5-epimerase |
| jadD | Cyclase/Dehydratase | jadV | NDP-hexose-4-ketoreductase |
| jadF | Oxygenase/Dehydratase | jadR* | tet R homologue |
| jadG | Anthrone oxygenase | jadY | Unknown |
| jadH | Oxygenase/Dehydratase | jadZ | Unknown |