Table 2. Clinical characteristics, complete blood examination and bone marrow analyses of CMML patients in the PREACH-M trial stratified as CBL mutant vs. RAS pathway wildtype.
| Variable | Total (n = 17) | RAS pathway wildtype (n = 6) | CBL mutant (n = 11) | P-value |
|---|---|---|---|---|
| Gender | ||||
| Male, n (%) | 8 (47%) | 2 (33%) | 6 (55%) | 0.6199 |
| Female, n (%) | 11 (65%) | 4 (67%) | 5 (45%) | |
| Age (years) | ||||
| Mean (range) | 72 (56−86) | 73 (56−86) | 71 (56−79) | 0.2539 |
| WHO classification | ||||
| CMML-0, n (%) | 3 (18%) | 1 (17%) | 2 (18%) | 0.7964 |
| CMML-1, n (%) | 9 (53%) | 4 (67%) | 5 (45%) | |
| CMML-2, n (%) | 5 (29%) | 1 (17%) | 4 (36%) | |
| MD-CMML, n (%) | 7 (41%) | 4 (67%) | 3 (27%) | 0.1618 |
| MP-CMML, n (%) | 10 (59%) | 2 (33%) | 8 (73%) | |
| BM Blast (%) | ||||
| Mean (range) | 7.7 (1.0−17.0) | 5.3 (1.0−10.3) | 10.1 (4.0−17.0) | 0.0457 |
| WCC (×109/L) | ||||
| Mean (range) | 20.3 (4.9−74.1) | 13.8 (4.9−36.8) | 26.8 (6.9−74.1) | 0.0462 |
| Hb (g/L) | ||||
| Mean (range) | 106 (79−128) | 104 (79−124) | 107 (91−128) | 0.4893 |
| PLT (×109/L) | ||||
| Mean (range) | 89 (7−219) | 91 (7−219) | 88 (27−192) | 0.5000 |
| Neutrophils (109/L) | ||||
| Mean (range) | 10.6 (1.7−45.2) | 7.2 (1.7−23.3) | 14.0 (3.0−45.2) | 0.0608 |
| Monocytes (109/L) | ||||
| Mean (range) | 4.3 (0.7−12.2) | 3.1 (1.0−8.0) | 5.6 (0.7−12.2) | 0.0859 |
| CRP (mg/L) | ||||
| Mean (range) | 4.4 (1.7−18.9) | 5.2 (1.7−18.9) | 3.6 (0.7−7.3) | 0.4708 |
| Spleen craniocaudal length (cm) | ||||
| Mean (range) | 13.6 (10.2−20.6) | 12.0 (10.8−13.8) | 15.2 (10.2−20.6) | 0.0308 |
n number of patients; BM bone marrow; WCC white blood cell count; Hb haemoglobin; PLT platelet; CRP C-reactive protein; MD-CMML myelodysplastic CMML; MP-CMML myeloproliferative CMML
Mann-Whitney test was applied to continuous and Fisher’s exact test to categorical data for statistical analysis where P<0.05 was statistically significant.
2016 WHO Classification:
Based on BM blast %: CMML-0 PB <2%, BM <5%; CMML-1 PB 2–4%, BM 5–9%, CMML-2 PB>5%, BM 10–19%.
Based on WCC: MD-CMML WCC<13×109/L, MP-CMML WCC>13×109/L