Table 2. Pharmacists and physicians knowledge regarding ARC.
| Questions | Correct answers N(%) | Wrong answers N(%) | |
|---|---|---|---|
| 1. Which method is generally used to assess the renal function status of patients with ARC | 35(38.0) | 57(62) | |
| 2. What is the eGFR cutoff /threshold to determine ARC in a critically ill patient | 22(23.9) | 70(76.1) | |
| 3. Which conditions below have been identified as risk factors for ARC? | Burns | 36(39.1) | 56(60.9) |
| Haematological | 20(21.7) | 72(78.3) | |
| malignancies | 23(25.0) | 69(75.0) | |
| Major surgery | 15(16.3) | 77(83.7) | |
| Neutrophils with fever | 37(40.2) | 55(59.8) | |
| Severe trauma | 16(17.4) | 76(82.6) | |
| Male gender | 18(19.6) | 74(80.4) | |
| Young age < 55 | 62(67.4) | 30(32.6) | |
| Sepsis | 25(27.2) | 67(72.8) | |
| I am not sure | 67(72.8) | 25(27.2) | |
| 4. Which drug group is pharmacokinetically affected by the ARC? | β-lactams | 47(51.1) | 45(48.9) |
| Glycopeptide | 31(33.7) | 61(66.3) | |
| Aminoglycoside | 56(60.9) | 36(39.1) | |
| Anticoagulant | 15(16.3) | 77(83.7) | |
| Antiepileptic | 22(23.9) | 70(76.1) | |
| 5. what are the recommended strategies to manage antibiotics in ARC patient | Use the maximum approved dosing regimen | 32(34.8) | 60(65.2) |
| Administer doses in a prolonged or continuous infusion | 28(30.4) | 64(69.6) | |
| Therapeutic drug monitoring | 63(68.5) | 29(31.5) | |
| Switch to an alternative agent that is not largely renally eliminated | 41(44.6) | 51(55.4) | |
| 6. What proper modification should be made regarding the following antibiotics in the ARC setting? | Amoxicillin-Clavulanic acid | 27(29.3) | 65(70.7) |
| Piperacillin-Tazobactam | 23(39.1) | 69(60.9) | |
| Vancomycin | 4(4.3) | 88(95.7) | |
| linezolid | 3(3.3) | 89(96.7) | |
| 7. What is the recommended loading dose of vancomycin in the setting of ARC for adult | 30(32.6) | 62(67.4) | |
| 8. What is the recommended maintenance dose of vancomycin in the setting of ARC for an adult | 25(27.2) | 67(72.8) | |
| 9. How would you monitor vancomycin trough level in the presence of ARC | 22(23.9) | 70(76.1) | |
ARC, Augmented renal clearance; eGFR, estimated glomerular filtration rate.