Table 2. Methylome-wide significant findings (q < 0.1) for laughing gas and pudendal block in primary MWAS and follow-up with look-up replication.

Cell Type	Chr.	Location (bp)	Gene Name	Primary MWAS			Look-up Replication
				Partial Correlation	p value	q value	Partial Correlation	p value
Laughing gas
Granulocytes	3	162,317,671		0.59	4.40E-09	0.067	0.36	1.03E-03
Granulocytes	3	162,317,679		0.59	5.50E-09	0.067	0.33	3.06E-03
Pudendal block
Monocytes	2	223,333,925	SGPP2	0.55	7.91E-09	0.073	0.35	1.44E-03
Monocytes	2	223,333,933	SGPP2	0.54	1.51E-08	0.073	0.34	2.38E-03
Monocytes	4	114,685,189		0.54	1.47E-08	0.073	0.47	1.19E-05
Monocytes	4	114,685,229		0.55	6.94E-09	0.073	0.50	2.89E-06
Monocytes	11	5,166,625		0.54	1.51E-08	0.073	-	9.70E-02

Abbreviations—Chr, chromosome: bp, base pair. Partial correlation not reported for non-significant results.