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. 2024 Sep 6;15:1394477. doi: 10.3389/fimmu.2024.1394477

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Copyright © 2024 Zhou, Yang, Wang, Chen, Wei, Wu, Meng and Lyu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blockade of CD44 inhibits the accumulation of macrophages and alleviates ferroptosis during the development of renal IR. (A) Representative image of HE and Pas staining. (B) Damage score of renal tubular injury; (C) Renal function detection; (D) The representative image of TUNEL staining; (E) The percentage of Tunel positive cell. (F) The representative image of immunofluorescence staining of GPX4; (G) Mean fluorescence intensity of GPX4. (H) GSH and MDA level in kidney tissue. (I) The representative image of transmission electron microscopy. (J) Macrophages infiltrated into kidney. **** represents P<0.0001, *** represents P<0.001, ** represents P<0.01, * represents P<0.05.