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. 2024 Sep 6;5:1418145. doi: 10.3389/ffunb.2024.1418145

Table 2.

Functional annotations of the top 30 orthogroups that were expanded in psychrophilic species based on t-score analysis.

Orthogroup Uniprot50 Blast Annotation Functional group Number of members
OG0000073 Aquaporin-1 231
OG0000122 Cell wall integrity and stress response
component (WSC) domain
Stress-related 185
OG0000354 Gfd2/YDR514C-like C-terminal domain DNA/RNA regulation 113
OG0000514 Enoyl reductase (ER) domain
Alcohol dehydrogenase GroES-like domain
PKS 95
OG0000606 Major facilitator superfamily (MFS) domain Membrane transporter 87
OG0000643 Clr5 domain* 85
OG0000704 Isochorismatase-like domain 81
OG0000712 NAD(P)-binding protein
Cyclin-dependent kinases regulatory subunit
80
OG0001090 3-phytase
Phosphoglycerate mutase-like protein
65
OG0001729 MFS-type transporter prx5
Major facilitator superfamily (MFS) profile domain
Membrane transporter 60
OG0002864 MFS general substrate transporter
Major facilitator superfamily (MFS) profile domain
Membrane transporter 58
OG0003444 Chromo domain 57
OG0005782 BTB domain 52
OG0005828 Zn(2)-C6 fungal-type domain DNA/RNA regulation 52
OG0005932 Pyruvate carboxylase 52
OG0006140 AB hydrolase-1 domain 50
OG0006802 Glycoside hydrolase family 1 protein CAZyme 42
OG0006821 Uncharacterized protein 42
OG0006937 EthD domain Oxidoreductase 40
OG0007051 Phytanoyl-CoA dioxygenase family protein Stress-related 38
OG0007114 Uncharacterized protein 37
OG0007171 MFS general substrate transporter Membrane transporter 36
OG0007215 G-patch domain DNA/RNA regulation 35
OG0007216 Dienelactone hydrolase domain 35
OG0007349 Oxidoreductase 32
OG0007504 Peptidase M20 dimerization domain 30
OG0007535 Helicase-associated domain
Helicase-like protein
DNA/RNA regulation 29
OG0007561 Alpha-mannosyltransferase alg11p protein 29
OG0008263 Succinate dehydrogenase assembly factor 4, mitochondrial PKS 20
OG0008563 Zn(2)-C6 fungal-type domain DNA/RNA regulation 17

*Only the consensus representative sequence of the Uniref50 cluster obtained by BLAST supported the annotation but no other members in the cluster have a reported annotation.