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. 2024 Mar 19;29(8):2510–2526. doi: 10.1038/s41380-024-02517-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A In the novel object test, mice were allowed to explore two objects and exposed 24 h later to one identical object and one novel object. Left panel: time to reach 20 s of exploration time (time to criterion) (Interaction: F(1,21) = 0.07123, p = 0.7922; sex: F(1,21) = 0.7263, p = 0.4037; genotype: F(1,21) = 1.383, p = 0.2527).; middle panel: the total exploration time (Interaction: F(1,21) = 0.07502, p = 0.7868; sex: F(1,21) = 0.1348, p = 0.7172; genotype: F(1,21) = 1.005, p = 0.3275); right panel: discrimination index (positive index indicating novel object preference) (Interaction: F(1,21) = 6.929, p = 0.0156; sex: F(1,21) = 0.5055, p = 0.4849; genotype: F(1,21) = 3.314, p = 0.0830). B In contextual fear conditioning, mice were shocked in context A, and compared for percent time spent freezing in context A or context B (left panels) for males (Context*genotype: F(1,20) = 0.3274, p = 0.5736; context: F(1,20) = 14.23, p = 0.0012; genotype: F(1,20) = 4.364, p = 0.0497; subject: F(1,21) = 1.526, p = 0.1763), female (Context*genotype: F(1,20) = 0.2471, p = 0.1127; context: F(1,21) = 88.29, P < 0.0001; genotype: F(1,21) = 0.02413, p = 0.8780; subject: F(1,21) = 2.371, p = 0.0270) differential freezing was compared using a discrimination index (right panel) (Interaction: F(1,41) = 5.532, p = 0.0236; sex: F(1,41) = 9.620, p = 0.0035; genotype: F(1,41) = 0.01023, p = 0.9199). Data represent individual mice, n = 5–13 per group. Statistics: Panel A – Two-way ANOVA with Sidak post-tests. Panel B – Two-way repeated measures ANOVA. *p < 0.05, **p < 0.01, ****p < 0.0001. Bars, mean ± SD.