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. 2024 Mar 19;29(8):2510–2526. doi: 10.1038/s41380-024-02517-5

Fig. 5. Sex differences in putative PV neurons emerge during early postnatal development and are dependent on gephyrin phosphorylation.

Fig. 5

Male and female WT and GphnS268A/S270A mice were crossed to Nkx2.1-Cre: Ai14-tdT to label putative hippocampal PV neurons with tdTomato at p0, p4, and p7. A tdT+ soma density within CA1 at p0 (Interaction: F(1,16) = 0.08385, p = 0.7759; genotype: F(1,16) = 24.30, p = 0.0002; sex: F(1,16) = 0.5384, p = 0.4737). B tdT+ soma density within CA1 stratum pyramidale at p4 (Interaction: F(1,24) = 0.1332, p = 0.7183; genotype: F(1,24) = 0.2843, p = 0.5988; sex: F(1,24) = 1.292, p = 0.2669). C tdT+ soma density within CA1 stratum pyramidale at p7 (Interaction: F(1,18) = 7.785, p = 0.0121; sex: F(1,18) = 2.054, p = 0.1690; genotype: F(1,18) = 4.528, p = 0.0474). Data represent individual averages across 6–12 sections. Statistics: All panels – two-way ANOVA with Sidak post-tests *p < 0.05. *p < 0.01. Bars, mean ± SD.