Table 1.

Comparative pathologic findings among the described tumors in this cohort.

Histopathological feature	Individual 1 RGNT	Individual 2 RGNT	Individual 3 Glioneuronal neoplasm with worrisome molecular features, NEC	Individual 4 Low-grade glioneuronal tumor, NEC	Individual 5 DNET
Rosenthal fibers	No	No	No	No	No
Eosinophilic granular bodies	Yes	No	No	No	No
Neurocytic cells	Yes	Yes	No	No	No
Ganglion cells	Yes	No	No	No	Yes
Mitoses	Few	No	No	No	No
Microvascular proliferation	Yes	No	No	Yes	No
Hyalinized vessels	No	No	No	No	No
Microcalcification	Yes	No	No	Yes	No
Mucinous microcystic matrix	Yes	No	No	Yes, focal	Yes
Tumor infiltration	None	Focal	Dural and leptomeningeal involvement	None	Yes
Perivascular pseudorosettes	Yes	No	No	No	No
Rosettes with neuropil cores	Yes	Yes	No	No	No
Ki-67 index	5%–10%	<3%	<5%	<3%	<3%
GFAP	Partially positive	Partially positive	Focally positive	Positive	Partially positive
Synaptophysin	Partially positive	Partially positive	Highlights very rare cells	Partially positive	Partially positive

DNET, dysembryoplastic neuroepithelial tumor; NEC, not elsewhere classified; RGNT, rosette-forming glioneuronal tumor.