Table 3.
Combined outcome mortality and fidgety movements of very preterm neonates in the NIRS group and in the control group. Poor outcome is defined as mortality before 20 weeks of corrected age or pathological fidgety movements between six to 20 weeks of corrected age. Neonatal morbidities at term age or before discharge of very preterm neonates in the NIRS group and in the control group. Data are presented as n (%). Relative Risk [95% CI] and p-value of the Relative Risk are provided
| NIRS group n = 82 |
Control group n = 89 |
Relative Risk [95% CI] | p-value | |
|---|---|---|---|---|
| Combined outcome mortality and fidgety movements | ||||
| Normal outcome | 74 (90.2) | 80 (89.9) | 0.96 [0.31–2.62] | 0.938 |
| Poor outcome | 8 (9.8) | 9 (10.1) | ||
| Neonatal morbidities at term age or before discharge | ||||
| Death and/or cerebral injury, n (%) | 8 (9.8) | 17 (19.1) | 0.51 [0.23–1.12] | 0.084 |
| Death, n (%) | 4 (4.9) | 4 (4.5) | 1.00 [0.93–1.06] | 1.000 |
| IVH any grade, n (%) | 6 (7.3) | 14 (15.7) | 0.46 [0.19–1.15] | 1.000 |
| No IVH, n (%) | 76 (92.7) | 75 (84.3) | 0.25 | |
| IVH I-II, n (%) | 4 (4.9) | 10 (11.2) | ||
| IVH III-IV, n (%) | 2 (2.4) | 4 (4.5) | ||
| Cystic PVL any grade, n (%) | 1 (1.2) | 1 (1.1) | 1.09 [0.07–17.07] | 1.000 |
| No cystic PVL, n (%) | 81 (98.8) | 88 (98.9) | 0.731 | |
| Cystic PVL II, n (%) | 0 (0.0) | 1 (1.1) | ||
| Cystic PVL III, n (%) | 1 (1.2) | 0 (0.0) | ||
| IRDS any grade, n (%) | 77 (93.9) | 84 (94.4) | 0.99 [0.92–1.07] | 1.000 |
| No IRDS, n (%) | 5 (6.1) | 5 (5.6) | 0.619 | |
| IRDS grade 1–2, n (%) | 67 (81.7) | 68 (76.4) | ||
| IRDS grade 3–4, n (%) | 10 (12.2) | 16 (18.0) | ||
| Culture proven sepsis, n (%) | 19 (23.2) | 23 (25.8) | 0.90 [0.53–1.52] | 0.164 |
| NEC any grade, n (%) | 3 (3.7) | 1 (1.1) | 3.26 [0.35–30.68] | 0.351 |
| BPD, n (%) | 7 (8.5) | 9 (10.1) | 0.84 [0.32–2.16] | 0.125 |
| ROP grade ≥ 2, n (%) | 7 (8.5) | 11 (12.4) | 0.69 [0.28–1.70] | 0.463 |
| PDA with interventions, n (%) | 4 (4.9) | 9 (10.1) | 0.48 [0.15–1.51] | 0.197 |
BDP bronchopulmonary dysplasia, IRDS infant respiratory distress syndrome, IVH intraventricular haemorrhage, NEC necrotizing enterocolitis, PDA persistent ductus arteriosus, PVL periventricular leukomalacia, ROP retinopathy of prematurity