TABLE 2.
Cells (%) | Groups (median—IQR) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Orchiectomy (n = 19) | HC | p | Chemotherapy (n = 35) | HC | p | BMT (n = 11) | HC | p | |
Naïve CD4 | 200 (118–362) | 206 (130–336) | 0.4307 | 139 (100–274) a | 210 (156–340) | 0.03 | 124.1 (39.6–176) a | 206 (156–369) | 0.0402 |
CM CD4 | 240 (208–428) | 200 (141–277) | 0.0714 | 230.4 (157.5–282.3) | 194.8 (129.3–316.2) | 0.8146 | 174.6 (57.8–427) | 207 (149.3–300.9) | 0.8311 |
EM CD4 | 74.5 (49–91.6) | 59.4 (26.4–93.1) | 0.4586 | 115.9 (66.3–295.5) a | 68.6 (33.4–97.3) | <0.0001 | 42.5 (16.1–176.1) | 68.6 (26–80.3) | 0.4648 |
TEMRA CD4 | 22.8 (4.71–69.8) | 28.4 (2.13–147) | 0.6777 | 28.4 (0.7–73.7) | 34.9 (16.4–86.2) | 0.9549 | 36.5 (1.2–66.3) | 18.2 (0.7–48.7) | 0.8265 |
Naïve CD8 | 93.4 (51.9–146) | 118 (90.8–262) | 0.8442 | 78.9 (41.5–192.6) | 121.6 (85.5–205) | 0.1442 | 104.7 (69.8–145.4) | 102.2 (69.6–319.7) | 0.9658 |
CM CD8 | 40.9 (5.58–94) | 34.4 (27–176) | 0.2247 | 16.1 (7.09–164.9) a | 39.8 (20–6‐139.6) | 0.02 | 38.1 (6.9–336.9) | 34.3 (31.3–67.0) | 0.6377 |
EM CD8 | 29 (20.5–79) | 82 (12.2–128) | 0.2435 | 97.8 (65–127.8) a | 49.6 (5.6–113) | 0.021 | 18.5 (0.9–50.7) | 81.9 (11.4–89.7) | 0.0663 |
TEMRA CD8 | 36 (8.92–74.6) | 30.7 (2.21–112) | 0.6322 | 28.9 (11.1–46.2) a | 10.8 (0–26.84) | 0.0067 | 22.6 (0–60.2) | 44.3 (0–76.7) | 0.5703 |
Naïve B cells | 79.5 (63.5–85.3) | 70.6 (63.5–85.3) | 0.625 | 81.5 (74.8–91.9) | 71.7 (62.1–78.9) | 0.6696 | 85.5 (77.6–89) | 0,6994 | 0.6994 |
Memory B cells | 31.4 (16.4–61.1) | 55.2 (9.51–68.4) | 0.6888 | 22.8 (14.2–44.8) a | 62.6 (31.2–73.1) | 0.0003 | 23.2 (7.84–39.5) | 59.8 (23.8–81.1) | 0.0652 |
Plasmablasts | 0.12 (0.02–0.22) a | 0.72 (0.32–0.90) | 0.0055 | 0.46 (0.12–1.21) | 0.37 (0.03–0.90) | 0.8913 | 0.05 (0–0.18) a | 0.37 (0.12–0.90) | 0.0081 |
Note: Bold values intended to highlight significant differences and the p value is highlighted in Blue.
Abbreviations: CM, Central Memory; EM, Effector Memory.
Naïve.